Mitragyna Speciosa Alkaloid Guide

Unlocking the Secrets of Kratom Alkaloids

Have you ever wondered how Mitragyna speciosa effects occur? The answer lies in its alkaloids, naturally occurring compounds that form the foundation of its complex profile. These alkaloids, embedded within the plant's leaves, define its potency and characteristics.

What Are Alkaloids?

Alkaloids are nitrogen-containing organic compounds found in various plants, fungi, bacteria, and even some animals. Their role in nature remains a topic of debate—some theories suggest they deter predators, while others view them as byproducts of nitrogen metabolism. The scientific study of alkaloids began in the 19th century, leading to the discovery of numerous significant compounds, including caffeine—a well-known alkaloid found in coffee and a close relative of mitragyna speciosa alkaloids.

Main Alkaloids:

Kratom contains over 25 alkaloids, but two stand out as the most influential:

Mitragynine

Mitragynine is the most abundant alkaloid in kratom, comprising 60-70% of its total alkaloid content. It plays a crucial role in defining the plant's profile. Its unique structure allows it to interact with multiple receptors in the body, giving it its multifaceted properties.

7-Hydroxymitragynine

Although mitragynine dominates in volume, 7-hydroxymitragynine is far more potent. This alkaloid in its all-natural form, which comprises only 2% or less of kratom's total alkaloid content, has a remarkably high affinity for the body's receptors. It forms through a simple oxidation process of mitragynine, significantly enhancing its potency.

The stark contrast between the concentration and potency of 7-hydroxymitragynine highlights the importance of not just quantity, but also the interaction and quality of alkaloids in kratom.

Other Noteworthy Kratom Alkaloids

Beyond mitragynine and 7-hydroxymitragynine, mitragyna speciosa (kratom) contains at least 23 additional alkaloids, each contributing to the plant’s complexity. Some of these include:

  • Paynantheine – The second most abundant alkaloid, making up 8-9% of kratom’s total alkaloid content.
  • Speciogynine – Another indole alkaloid, constituting approximately 6-7% of the plant’s alkaloid profile.
  • Mitraphylline & Isomitraphylline – Present in smaller quantities, these alkaloids possess distinct characteristics.
  • Speciophylline & Rhynchophylline – Also found in other members of the coffee family, like Cat’s Claw, showcasing the botanical diversity of kratom.
  • Akuammigine, Ciliaphylline, & Isopteropodine – Each of these alkaloids adds to kratom’s unique chemical makeup.

Despite growing knowledge of these compounds, much remains to be discovered about their full potential and interactions with each other

Continued Research

Kratom’s chemical complexity continues to intrigue researchers. Fortunately, increasing interest has led to more studies exploring its properties. The University of Florida College of Pharmacy, led by kratom research pioneer Christopher McCurdy, is conducting groundbreaking studies on mitragyna speciosa alkaloids and its mechanisms and potential over the next seven years.

Stay In The Loop with Mitrafeel

While mitragynine and 7-hydroxymitragynine dominate discussions, a treasure trove of uncharted compounds remains. Research is ongoing, and the future research looks promising.

Visit our blog for more insights or view our products to try it out today!